Welcome to MISTIC!

Mutual Information Server to Infer Coevolution

> > NEW version available here! < <

MISTIC is a complete web tool that aims to estimate the mutual coevolutionary relationship between two residues in a protein family using corrected Mutual Information (MI). Correlations between positions in a Multiple Sequence Alignment may prove structurally or functionally important in a given fold or protein family, becoming interesting targets for study.

Advanced Options